Water → HCID 22316930、化合物

HRID 910220ノート

反応式

HRID 910220 の反応式
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C1(C)C=CC(S([CH2:21][N:22]=C=O)(=O)=O)=CC=1.[C:26](=O)([O-])[O-].[K+].[K+].O>CO>[O:3]1[C:1]([C:4]2[CH:11]=[CH:10][C:7]([C:8](=[O:9])[CH3:26])=[CH:6][CH:5]=2)=[CH:2][N:22]=[CH:21]1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 5009465Benzaldehyde, 4-acetyl-HCID 117890781-Isocyanatomethanesulfonyl-4-methylbenzene

生成物 1

HCID 22316930HCID 22316930、化合物収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-Acetylbenzaldehyde (2.96 g) and p-toluenesulfonylmethylisocyanate (4.69 g) were dissolved in methanol (200 mL). Potassium carbonate (3.32 g) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The solvent was evaporated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1), followed by concentration under reduced pressure, to thereby yield the title compound (3.14 g).

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. customThe solvent was evaporated
  3. customthe residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1)
  4. concentrationfollowed by concentration under reduced pressure

出典と根拠

ORDレコード
ord-237d81c8fa0d45dd944acb723a4abb9f
出典データセット
uspto-grants-2011_09
特許番号
US08022075B2

反応ノート

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