2-Amino-5-bromopyrimidine → 5-[4-(6-Bromoimidazo[1,2-a]pyrimidin-2-yl)phenyl]-1,3-oxazole

HRID 910222ノート

反応式

HRID 910222 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>O1CCOCC1>[Br:8][C:5]1[CH:4]=[N:3][C:2]2[N:7]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:6]=1

参加物

4

反応物 2

HCID 2313102-Amino-5-bromopyrimidineHCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

生成物 1

HCID 674055005-[4-(6-Bromoimidazo[1,2-a]pyrimidin-2-yl)phenyl]-1,3-oxazole収率 86.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Amino-5-bromopyrimidine (348 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (532 mg) were suspended in 1,4-dioxane (20 mL), followed by refluxing under heating overnight. Immediately after refluxing, the reaction mixture was filtered without being cooled, followed by washing with heated 1,4-dioxane and drying, to thereby yield the title compound (587 mg).

後処理

  1. temperatureby refluxing
  2. temperatureunder heating overnight
  3. temperatureImmediately after refluxing
  4. filtrationthe reaction mixture was filtered
  5. temperaturewithout being cooled
  6. washby washing with heated 1,4-dioxane
  7. customdrying

出典と根拠

ORDレコード
ord-7d9150ae60a447fe97a2c80da206e44c
出典データセット
uspto-grants-2011_09
特許番号
US08022075B2

反応ノート

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