2-Amino-5-chloropyridine → 5-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

参加物

反応物 2

HCID 661742-Amino-5-chloropyridine

HCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

生成物 1

HCID 252041195-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole収率 27%

実験手順

The procedure of Referential Example 1 was repeated, except that 2-amino-5-chloropyridine (49 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (100 mg), which had been produced in Referential Example 10 were used, to thereby yield the title compound (30 mg).

後処理

customhad been produced in Referential Example 10

出典と根拠

ORDレコード: ord-3fcb4a2578e24390a13189413608667a
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08022075B2

反応ノート

読み込み中…

参加物