Acetic Acid → 2-Amino-5-bromobenzene-1-thiol
反応式
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:7]=2[N:8]=1.C(O)(=O)C>O>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([Br:13])=[CH:12][C:6]=1[SH:5]参加物
5
実験手順
Potassium hydroxide (39.6 g) was dissolved at 0° C. in water (80 mL), and 2-amino-6-bromobenzothiazole (6.87 g) was added to the solution, followed by refluxing under heating overnight. The mixture was returned to room temperature, and then neutralized with 5N aqueous acetic acid solution. The precipitated crystals were recovered through filtration, washed with water, and dried under reduced pressure with heating, followed by recrystallization from isopropyl ether, to thereby yield the title compound (3.87 g).
後処理
- temperatureby refluxing
- temperatureunder heating overnight
- customwas returned to room temperature
- filtrationThe precipitated crystals were recovered through filtration
- washwashed with water
- customdried under reduced pressure
- temperaturewith heating
- customfollowed by recrystallization from isopropyl ether
出典と根拠
- ORDレコード
- ord-95dfb255a5eb49f497aad75ae6f1451b
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022075B2
反応ノート
読み込み中…