Acetic Acid → 2-Amino-5-bromobenzene-1-thiol

HRID 910229

反応式

HRID 910229 の反応式
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([Br:13])[CH:10]=[CH:9][C:7]=2[N:8]=1.C(O)(=O)C>O>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([Br:13])=[CH:12][C:6]=1[SH:5]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 851492-Benzothiazolamine, 6-bromo-

生成物 1

HCID 12090452-Amino-5-bromobenzene-1-thiol収率 63.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Potassium hydroxide (39.6 g) was dissolved at 0° C. in water (80 mL), and 2-amino-6-bromobenzothiazole (6.87 g) was added to the solution, followed by refluxing under heating overnight. The mixture was returned to room temperature, and then neutralized with 5N aqueous acetic acid solution. The precipitated crystals were recovered through filtration, washed with water, and dried under reduced pressure with heating, followed by recrystallization from isopropyl ether, to thereby yield the title compound (3.87 g).

後処理

  1. temperatureby refluxing
  2. temperatureunder heating overnight
  3. customwas returned to room temperature
  4. filtrationThe precipitated crystals were recovered through filtration
  5. washwashed with water
  6. customdried under reduced pressure
  7. temperaturewith heating
  8. customfollowed by recrystallization from isopropyl ether

出典と根拠

ORDレコード
ord-95dfb255a5eb49f497aad75ae6f1451b
出典データセット
uspto-grants-2011_09
特許番号
US08022075B2

関連ノート

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