化工社化工社 化学情報印刷レポート · 研究参考用
Acetone → 3-(4-Isopropyl-piperazin-1-yl)-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(4-Isopropyl-piperazin-1-yl)-phenol | HCID 58499480 | 59.9% |
反応手順
Acetone (1.95 g) and NaBH(OAc)3 (7.12 g) were added to a solution of 3-piperazin-1-yl-phenol (2.00 g) in THF (40 ml), and the mixture was stirred at room temperature for 18 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and filtered to give the titled compound (1.48 g, colorless powder).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022091B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-f0cc949488174e2aa69b178879108f42 |
| 出典メモ | uspto-grants-2011_09 |