(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 910320ノート

反応式

HRID 910320 の反応式
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

生成物 1

HCID 534852236-Iodopyridine-3-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒2 回

実験手順

63 g (723 mmol) of manganese dioxide are added to a solution of 17 g (72 mmol) of (6-iodopyrid-3-yl)methanol in 600 ml of dichloromethane. The reaction medium is stirred at room temperature for 20 hours and then filtered through Celite. The precipitate is washed thoroughly with water and the filtrate is evaporated under vacuum. The residue obtained is taken up in dichloromethane and the insoluble material is again filtered off. After evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde are obtained in the form of a pale yellow solid with a melting point of 141° C.

後処理

  1. filtrationfiltered through Celite
  2. washThe precipitate is washed thoroughly with water
  3. customthe filtrate is evaporated under vacuum
  4. customThe residue obtained
  5. filtrationthe insoluble material is again filtered off
  6. customAfter evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde
  7. customare obtained in the form of a pale yellow solid with a melting point of 141° C.

出典と根拠

ORDレコード
ord-2c710a88300845a1a6d24fc70fd6f30a
出典データセット
uspto-grants-2011_09
特許番号
US08022079B2

反応ノート

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