Water → 4-benzyl-5-isopropyl-3-(2,3,4,6-tetra-O-pivaloyl-betaD-glucopyranosyloxy)-1H-pyrazole

HRID 910599ノート

反応式

HRID 910599 の反応式
[CH2:1]([C:8]1[C:9]([O:18][C@@H:19]2[O:45][C@H:44]([CH2:46][O:47][C:48](=[O:53])[C:49]([CH3:52])([CH3:51])[CH3:50])[C@@H:36]([O:37][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40])[C@H:28]([O:29][C:30](=[O:35])[C:31]([CH3:34])([CH3:33])[CH3:32])[C@H:20]2[O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])=[N:10][N:11](C=O)[C:12]=1[CH:13]([CH3:15])[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].O>CO>[CH2:1]([C:8]1[C:9]([O:18][C@@H:19]2[O:45][C@H:44]([CH2:46][O:47][C:48](=[O:53])[C:49]([CH3:50])([CH3:52])[CH3:51])[C@@H:36]([O:37][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40])[C@H:28]([O:29][C:30](=[O:35])[C:31]([CH3:32])([CH3:34])[CH3:33])[C@H:20]2[O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:24])[CH3:25])=[N:10][NH:11][C:12]=1[CH:13]([CH3:15])[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 67349861HCID 67349861、化合物

生成物 1

HCID 673494844-benzyl-5-isopropyl-3-(2,3,4,6-tetra-O-pivaloyl-betaD-glucopyranosyloxy)-1H-pyrazole収率 97.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-benzyl-1-formyl-5-isopropyl-3-(2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyloxy)-1H-pyrazole (1.49 g) in methanol (15 mL) was added sodium bicarbonate (0.337 g) under stirring at room temperature. The reaction mixture was stirred at room temperature for 11 hours. After confirming the completion of the reaction, water was added to the mixture to precipitate the crystals. The crystals were collected by filtration, and the obtained crystals were washed with water and dried under reduced pressure to give 4-benzyl-5-isopropyl-3-(2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl-oxy)-1H-pyrazole (1.40 g).

後処理

  1. stirringThe reaction mixture was stirred at room temperature for 11 hours
  2. additionwas added to the mixture
  3. customto precipitate the crystals
  4. filtrationThe crystals were collected by filtration
  5. washthe obtained crystals were washed with water
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-1a3e32e0a4a2434994fd5f1edda5836a
出典データセット
uspto-grants-2011_09
特許番号
US08022192B2

反応ノート

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