Ammonium Acetate → (s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

HRID 910762ノート

反応式

HRID 910762 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH2:13][C:14](=O)[CH3:15])[CH3:10])=[CH:5][CH:4]=1.C([O-])(=O)C.[NH4+:22]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH:13]=[C:14]([NH2:22])[CH3:15])[CH3:10])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 86624412(1S)-N-[1-(4-Methoxy-phenyl)-ethyl]-3-oxo-butyramide

生成物 1

HCID 67417518(s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

To a suspension of (S)—N-[1-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide (10 g) in toluene (800 ml) was added at 20° C. ammonium acetate (10 g) and the reaction was heated for 20 h at 100° C. in a Dean Stark system. The mixture was concentrated in vacuo and the product obtained was used without further purification in the following reaction step.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe product obtained
  3. customwas used without further purification in the following reaction step

出典と根拠

ORDレコード
ord-604860e08133494c8cb94413d7eda6e1
出典データセット
uspto-grants-2011_09
特許番号
US08022218B2

反応ノート

読み込み中…