Dimethylformamide → 4-Chloro-2-(methylthio)benzaldehyde
反応式
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1C=O.[CH3:11][S-:12].[Na+].CN([CH:17]=[O:18])C>O>[Cl:1][C:2]1[CH:3]=[CH:6][C:7]([CH:17]=[O:18])=[C:8]([S:12][CH3:11])[CH:9]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
The subtitle compound was prepared by using 2-chloro-4-fluorobenzaldehyde (1.16 g) in dry DMF (20 ml). The mixture was treated with sodium thiomethoxide (0.52 g) and heated to 50° C. for 2 hours. The mixture was diluted with water, extracted with ethyl acetate, dried and concentrated under reduced pressure to give a solid. The residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1 to give a white solid, yield 0.70 g.
後処理
- extractionextracted with ethyl acetate
- customdried
- concentrationconcentrated under reduced pressure
- customto give a solid
- customThe residue was purified by chromatography on silica eluting with isohexane/diethylether 2:1
- customto give a white solid, yield 0.70 g
出典と根拠
- ORDレコード
- ord-4cd3fac65bf5437cba65cda14e5e38d1
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022248B2
反応ノート
読み込み中…