Hydrochloric Acid → HCID 178431958、化合物
反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[S:17][CH:18]=[C:19]([CH3:21])[N:20]=2)[CH:10]=1)C1C=CC=CC=1.Cl>>[CH3:21][C:19]1[N:20]=[C:16]([NH:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][N:12]=2)[S:17][CH:18]=1参加物
3
実験手順
Following the method of Example 3, Step A, 4-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine (prepared according to Example 17) (2.3 g, 7.73 mmol), and HCl (38.7 mL, 116 mmol) (3M HCl) were reacted to provide 2-(4-methylthiazol-2-ylamino)pyridin-4-ol (0.620 g, 38.7% yield) as white solid. 1H NMR (CDCl3) δ 7.38 (bs, 1H), 6.23 (m, 2H), 6.10 (bs, 1H), 2.28 (s, 3H). HPLC (5 to 95) Rt=1.82 min; Mass spectrum (esi) m/z=208 (M+H).
後処理
- customwere reacted
出典と根拠
- ORDレコード
- ord-f5a011ecc1e64efb878d0c77616b852f
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022222B2
反応ノート
読み込み中…