化工社化工社 化学情報印刷レポート · 研究参考用
2,6-Dimethylphenol → 2-Chloro-4-(2,6-dimethylphenoxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dimethylphenol | HCID 11335 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Chloro-4-nitropyridine | HCID 735152 | — |
| 生成物 | 2-Chloro-4-(2,6-dimethylphenoxy)pyridine | HCID 86634736 | 96.3% |
反応手順
Using the method of Example 3, Step A, 2,6-dimethylphenol (0.771 g, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to provide 2-chloro-4-(2,6-dimethylphenoxy)pyridine (1.42 g, 96% yield) as a white solid. 1H NMR (CDCl3) δ 8.20 (d, 1H), 7.12 (s, 4H), 6.65-6.68 (m, 2H), 2.11 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022222B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-4063f08ca8f346c7ad8604fa9a1f063c |
| 出典メモ | uspto-grants-2011_09 |