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Potassium Phosphate, Tribasic → HCID 24826661、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 2-Amino-4-methylthiazole | HCID 74143 | — |
| 反応物 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 反応物 | 2-Chloro-4-(2,6-dimethylphenoxy)pyridine | HCID 86634736 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 生成物 | HCID 24826661 | HCID 24826661 | 44% |
反応手順
Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.244 g, 2.14 mmol), 2-chloro-4-(2,6-dimethylphenoxy)pyridine (0.500 g, 2.14 mmol), potassium phosphate (0.500 g, 2.35 mmol), Pd2(dba)3 (0.098 g, 0.107 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.062 g, 0.107 mmol) were reacted to provide N-(4-(2,6-dimethylphenoxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.290 g, 44% yield). 1H NMR (d6-DMSO) δ 10.93 (s, 1H), 8.13 (d, 1H), 7.15-7.22 (m, 3H), 6.50 (s, 1H), 6.40 (d, 1H), 6.39 (s, 1H), 2.19 (s, 3H), 2.08 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022222B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-d7431034cea649d9bd06fcef084ef778 |
| 出典メモ | uspto-grants-2011_09 |