N,N-Dimethylethylenediamine → HCID 86634755、化合物
反応式
[ClH:1].[CH3:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1[O:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[S:21][CH:22]=[C:23]([CH3:25])[N:24]=2)[CH:14]=1.[CH3:26][N:27]([CH3:31])[CH2:28][CH2:29][NH2:30]>>[ClH:1].[ClH:1].[CH3:26][N:27]([CH3:31])[CH2:28][CH2:29][NH:30][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][C:3]([CH3:2])=[C:4]([O:12][C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]3[S:21][CH:22]=[C:23]([CH3:25])[N:24]=3)[CH:14]=2)[CH:5]=1参加物
3
実験手順
The title compound was prepared according to the method of Example 107 from 4-methyl-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid hydrochloride (Example 108) and N,N-dimethylethylenediamine. Yield: 0.065 g, 25%. 1H NMR (CDCl3), 8.84 (bs, 1H), 8.16 (d, 1H), 7.90 (d, 1H), 7.86 (bs, 1H), 7.37 (d, 1H), 6.80 (bs, 1H), 6.71 (dd, 1H), 6.38 (s, 1H), 3.89 (m, 2H), 3.35 (m, 2H), 2.91 (s, 6H), 2.37 (s, 3H), 2.22 (s, 3H).
出典と根拠
- ORDレコード
- ord-55ee145dd2f84b838e91ff4e608d169d
- 出典データセット
- uspto-grants-2011_09