Bromine → HCID 66618159、化合物
反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:16]Br>C(O)(=O)C>[CH2:1]([O:8][C:9]1[C:14]([Br:16])=[CH:13][N:12]=[C:11]([NH2:15])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A flask was charged with 4-(benzyloxy)pyridin-2-amine (10.69 g, 53.39 mmol) and 20 mL acetic acid was added. Bromine (2.735 ml, 53.39 mmol) and the reaction was stirred for 10 minutes. The reaction mixture was concentrated and purified using silica gel column chromatography eluting with 50%-100% ethyl acetate/hexane provide the desired product (7.0 g, 42.28% yield) as brown solid
後処理
- additionwas added
- concentrationThe reaction mixture was concentrated
- custompurified
- washeluting with 50%-100% ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-e4cbcf9fd3a949c0835209272ad619cc
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022222B2
反応ノート
読み込み中…