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Diethyl Ether → 1-(6-Methylpyridin-2-yl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 6-Methyl-2-pyridinecarboxaldehyde | HCID 70737 | — |
| 反応物 | HCID 178418573 | HCID 178418573 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(6-Methylpyridin-2-yl)ethanol | HCID 353138 | — |
反応手順
To 6-methylpyridine-2-carboxaldehyde (2.0 g, 16.5 mmol) in dry THF (55 mL) at 0° C. under nitrogen, add a solution of 3M methyl magnesium bromide in ether (6.0 mL, 18.0 mmol) dropwise with stirring. After 1 h at 0° C., quench with saturated aqueous NH4Cl, extract three times with EtOAc, dry over anhydrous Na2SO4 and concentrate in vacuo to give the desired intermediate (crude, 2.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022062B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-e4e089cff6174624942de9363c4cc38b |
| 出典メモ | uspto-grants-2011_09 |