Triethylamine → HCID 86661654、化合物
反応式
[F:1][C:2]([F:12])([F:11])[C:3]([C:7]([F:10])([F:9])[F:8])([CH3:6])[CH2:4][OH:5].C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl.O>[F:1][C:2]([F:11])([F:12])[C:3]([CH3:6])([C:7]([F:9])([F:8])[F:10])[CH2:4][O:5][S:21]([CH3:20])(=[O:23])=[O:22]参加物
6
実験手順
To 2,2-bis(trifluoromethyl)propanol (4.34 g, 22.1 mmol) in DCM (100 mL) at 0° C. add with stirring triethylamine (6.2 mL, 44 mmol) followed by methanesulfonyl chloride (2.6 mL, 33 mmol). After 15 min at 0° C. dilute with water and extract three times with EtOAc. Dry over anhydrous Na2SO4 and concentrate in vacuo to give the crude desired intermediate as a yellow oil (6.16 g, 100%).
後処理
- extractionextract three times with EtOAc
- dry with materialDry over anhydrous Na2SO4
- concentrationconcentrate in vacuo
出典と根拠
- ORDレコード
- ord-14d2939c140f4b5e808ef25b54d4d027
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022062B2
反応ノート
読み込み中…