Methanol → (2-Fluoro-4-phenoxyphenyl)-methanol

HRID 911460ノート

反応式

HRID 911460 の反応式
[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][O:5]C1CCCCO1.CO.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CCOC(C)=O>[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][OH:5]

参加物

5

反応物 3

HCID 887MethanolHCID 521998p-Toluenesulfonic acid monohydrateHCID 576563912-(2-Fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran

生成物 1

HCID 57656488(2-Fluoro-4-phenoxyphenyl)-methanol収率 95%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Mix under nitrogen atmosphere 2-(2-fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran (2.05 g, 6.8 mmol), methanol (60 mL) and p-toluenesulfonic acid monohydrate (260 mg, 1.35 mmol). Stir at ambient temperature for 16 h. Dilute with EtOAc. Wash with saturated aqueous NaHCO3. Separate the organic layer, dry over Na2SO4 and concentrate in vacuo to give the desired intermediate (1.41 g, 95%). MS (ES+) m/z: 201 (M−OH)+.

後処理

  1. washWash with saturated aqueous NaHCO3
  2. customSeparate the organic layer
  3. dry with materialdry over Na2SO4
  4. concentrationconcentrate in vacuo

出典と根拠

ORDレコード
ord-71775c70acfe49d1a588168e31ccb9a5
出典データセット
uspto-grants-2011_09
特許番号
US08022062B2

反応ノート

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