4-(Chloromethyl)phenyl acetate → HCID 57656056、化合物

HRID 911521

反応式

HRID 911521 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:26]([O:29][C:30]1[CH:35]=[CH:34][C:33](CCl)=[CH:32][CH:31]=1)(=[O:28])[CH3:27]>>[C:26]([O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:21][S:20][C:15]2[C:12]3[CH2:13][CH2:14][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:9][CH2:10][C:11]=3[CH:18]=[CH:17][C:16]=2[Cl:19])=[CH:32][CH:31]=1)(=[O:28])[CH3:27]

参加物

3

反応物 2

HCID 1483124-(Chloromethyl)phenyl acetateHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

生成物 1

HCID 57656056HCID 57656056、化合物

実験手順

Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 4-(chloromethyl)phenyl acetate to give 6-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a white solid.

後処理

  1. customsimilar to the Preparation 177

出典と根拠

ORDレコード
ord-897100b63ff64991a19ac421ecb45a9b
出典データセット
uspto-grants-2011_09
特許番号
US08022062B2

関連ノート

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