1-(Bromomethyl)-2-methanesulfonylbenzene → 7-Chloro-6-(2-methanesulfonylbenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride
反応式
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[S:34]([CH3:37])(=[O:36])=[O:35]>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[S:34]([CH3:37])(=[O:36])=[O:35]参加物
3
実験手順
Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 1-bromomethyl-2-methanesulfonyl-benzene to give, after deprotection by the General Procedure 1-4, the title compound and as a white solid. MS (APCI+) m/z: 382 (M+H)+.
後処理
- customsimilar to the Preparation 177