Propanal → HCID 66995125、化合物

HRID 911821ノート

反応式

HRID 911821 の反応式
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

参加物

5

反応物 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

生成物 1

HCID 66995125HCID 66995125、化合物収率 225%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

後処理

  1. concentrationThe solution was concentrated
  2. customchromatographed

出典と根拠

ORDレコード
ord-a9d4ad6753aa4fba9ae239735904992f
出典データセット
uspto-grants-2011_09
特許番号
US08022223B2

反応ノート

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