Bromine → 1-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

HRID 911908ノート

反応式

HRID 911908 の反応式
[N:1]1([C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH3:8])[CH2:3][CH2:2]1.[Br:13]Br>CO>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH2:8][Br:13])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

参加物

4

反応物 2

HCID 24408BromineHCID 27772501,4-Diacetylpiperidine

生成物 1

HCID 772303261-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1,1′-(Piperidine-1,4-diyl)diethanone (38.0 g, 225 mmol) was dissolved in methanol (700 mL) and bromine (12.1 mL, 236 mmol) was added. After agitating for 3 hours the solvent was removed. The resulting solid was washed with ethyl acetate, then distributed between ethyl acetate and sodium carbonate. The organic phase was separated, washed with brine, dried and evaporated to give the title compound.

後処理

  1. customwas removed
  2. washThe resulting solid was washed with ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with brine
  5. customdried
  6. customevaporated

出典と根拠

ORDレコード
ord-ec871ec3268444dd86aae805128356d6
出典データセット
uspto-grants-2011_09
特許番号
US08022223B2

反応ノート

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