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4-Amino-2-methylquinoline → 3-[7-(2-Methyl-quinolin-4-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-2-methylquinoline | HCID 81116 | — |
| 反応物 | 4-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholine | HCID 59244988 | — |
| 反応物 | 4-[4-(3-Methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-quinoline | HCID 67386586 | — |
| 生成物 | 3-[7-(2-Methyl-quinolin-4-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol | HCID 24889093 | — |
反応手順
In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-methyl-quinolin-4-ylamine, 4-[4-(3-methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-quinoline was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022205B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-d2b0cc6453b4456ba7879daec7ebafed |
| 出典メモ | uspto-grants-2011_09 |