N,N-dimethyl-p-phenylenediamine → 3-[7-(4-Dimethylamino-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

HRID 912102ノート

反応式

HRID 912102 の反応式
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CN(C)C1C=CC(N)=CC=1.C[O:36][C:37]1[CH:38]=[C:39]([C:43]2[C:44]3[CH2:57][CH2:56][N:55]([C:58]4[CH:63]=[CH:62][C:61]([N:64]([CH3:66])[CH3:65])=[CH:60][CH:59]=4)[C:45]=3[N:46]=[C:47]([N:49]3[CH2:54][CH2:53][O:52][CH2:51][CH2:50]3)[N:48]=2)[CH:40]=[CH:41][CH:42]=1>>[CH3:65][N:64]([CH3:66])[C:61]1[CH:60]=[CH:59][C:58]([N:55]2[C:45]3[N:46]=[C:47]([N:49]4[CH2:50][CH2:51][O:52][CH2:53][CH2:54]4)[N:48]=[C:43]([C:39]4[CH:38]=[C:37]([OH:36])[CH:42]=[CH:41][CH:40]=4)[C:44]=3[CH2:57][CH2:56]2)=[CH:63][CH:62]=1

参加物

4

反応物 3

HCID 7472N,N-dimethyl-p-phenylenediamineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 673864804-(3-methoxy-phenyl)-7-(4-dimethylaminophenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

生成物 1

HCID 248897643-[7-(4-Dimethylamino-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

実験手順

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 4-dimethylaminoaniline, 4-(3-methoxy-phenyl)-7-(4-dimethylaminophenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

出典と根拠

ORDレコード
ord-cb2b2f0c3cb245a688337913c67e00c6
出典データセット
uspto-grants-2011_09
特許番号
US08022205B2

反応ノート

読み込み中…