(4-Ethylpiperazin-1-yl)-(4-methyl-3-nitrophenyl)methanone → 5-[(4-Ethylpiperazin-1-YL)carbonyl]-2-methylaniline

HRID 912154

反応式

HRID 912154 の反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N+:18]([O-])=O)[CH:12]=2)=[O:10])[CH2:5][CH2:4]1)[CH3:2]>CO.[C].[Pd]>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([NH2:18])[CH:12]=2)=[O:10])[CH2:5][CH2:4]1)[CH3:2]

参加物

4

反応物 1

HCID 808340(4-Ethylpiperazin-1-yl)-(4-methyl-3-nitrophenyl)methanone

生成物 1

HCID 167887345-[(4-Ethylpiperazin-1-YL)carbonyl]-2-methylaniline収率 105.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

(4-Ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone (1.06 g, 3.82 mmol) obtained in Step A was stirred for 16 hours in methanol (20 ml) under a hydrogen atmosphere in the presence of 10% palladium carbon. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure, to obtain (4-ethyl-piperazin-1-yl)-(3-amino-4-methyl-phenyl)-methanone (1.0 g, quant.).

後処理

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9e2899b8544e4cc8836a451aa78a67ff
出典データセット
uspto-grants-2011_09
特許番号
US08022205B2

関連ノート

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