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Acetonitrile → 3-(2-(4-Tert-butoxycarbonyl-piperazin-1-yl)-ethyl)-1-bromo-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 3-Bromophenethyl bromide | HCID 14361216 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(2-(4-Tert-butoxycarbonyl-piperazin-1-yl)-ethyl)-1-bromo-benzene | HCID 59244915 | 92.2% |
反応手順
To 3-(2-bromo-ethyl)-1-bromo-benzene (0.15 ml, 1 mmol), 1-tert-butoxycarbonyl-piperazine (186 mg) and potassium carbonate (280 mg), acetonitrile (4 ml) was added, followed by stirring for 4 days. To the reaction mixture, ethyl acetate was added, which was washed with ammonium chloride solution, followed by drying over sodium sulfate. After filtering off the drying agent, the filtrate was concentrated under reduced pressure, to obtain 3-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-ethyl)-1-bromo-benzene as a colorless oil (340 mg, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022205B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-593da5778212483a84c2edee09c15c65 |
| 出典メモ | uspto-grants-2011_09 |