Hydrochloric Acid → (3S)-3-amino-1-methylazepan-2-one hydrochloride

HRID 912455ノート

反応式

HRID 912455 の反応式
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]([NH:9]C(=O)OC(C)(C)C)[C:3]1=[O:17].[ClH:18].O1CCOCC1>ClCCl>[ClH:18].[NH2:9][C@H:4]1[CH2:5][CH2:6][CH2:7][CH2:8][N:2]([CH3:1])[C:3]1=[O:17]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 60110341(S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate

生成物 1

HCID 67416248(3S)-3-amino-1-methylazepan-2-one hydrochloride収率 99.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate (prepared according to Example 14; 0.152 g, 0.627 mmol) in dichloromethane (2 mL) was added 4M hydrogen chloride in dioxane (2 mL, 8 mmol), and the reaction mixture was allowed to stir overnight. The reaction mixture was concentrated to yield (S)-3-amino-1-methylazepan-2-one hydrochloride (0.112 g, 99.9% yield) which was taken on to the next step.

後処理

  1. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-43fee2b892c6427a9145b25bc553d2bb
出典データセット
uspto-grants-2011_09
特許番号
US08026233B2

反応ノート

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