Hydrochloric Acid → 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid
反応式
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:19])[OH:18])=[CH:13][C:12]=1[C:20]([F:23])([F:22])[F:21].Cl>>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:18])[OH:19])=[CH:13][C:12]=1[C:20]([F:23])([F:21])[F:22]参加物
3
反応条件
- 温度
- 60 °C
実験手順
4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid (8 g) was added to hydrochloric acid (1M in MeOH) and the mixture was heated at 60° C. for 60 minutes. Solvent and HCl was then removed under reduced pressure and residue (5.52 g) was used for next step without further purification.
後処理
- customSolvent and HCl was then removed under reduced pressure and residue (5.52 g)
- customwas used for next step without further purification
出典と根拠
- ORDレコード
- ord-85e19f2c4ac64c40a4820a4a0ef464a7
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08026236B2
反応ノート
読み込み中…