関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl isocyanate | HCID 8022 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Amino-6-benzylbenzothiazole | HCID 21985510 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(6-Benzyl-2-benzothiazolyl)-3-ethylurea | HCID 21985614 | 56% |
反応手順
A suspension of 2-amino-6-benzyl-benzothiazole (0.040 g, 0.17 mmol), triethylamine (0.104 mL, 0.77 mmol, 4.5 eq), and ethyl isocyanate (0.049 mL, 0.64 mmol, 3.8 eq) in 1 mL toluene was heated at about 95° C. for about 16 hours. The precipitate was filtered off, washed with Et2O and MeOH, and dried under vacuum to give the desired compound 0.029 g (56%). LC/MS 312.3 (M+1); LC retention time 2.62 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091227B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-507cd915806547c7b328f3dffb50e852 |
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| 出典メモ | uspto-grants-2006_08 |
|---|
