Sodium Dithionite → 5,6-Diamino-1-[(3-isopropylisoxazol-5-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

反応式

[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[O:13][N:12]=[C:11]([CH:14]([CH3:16])[CH3:15])[CH:10]=2)[C:6](=[S:17])[NH:5][C:4](=[O:18])[CH:3]=1.[N:19]([O-])=O.[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>>[NH2:19][C:3]1[C:4](=[O:18])[NH:5][C:6](=[S:17])[N:7]([CH2:8][C:9]2[O:13][N:12]=[C:11]([CH:14]([CH3:15])[CH3:16])[CH:10]=2)[C:2]=1[NH2:1]

参加物

反応物 3

HCID 24489Sodium Dithionite

HCID 23668193Sodium Nitrite

HCID 866311326-Amino-1-[(3-isopropylisoxazol-5-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

生成物 1

HCID 866311335,6-Diamino-1-[(3-isopropylisoxazol-5-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one収率 33.2%

実験手順

The title compound was prepared in accordance with the general method described in Example 12(c) by using 6-amino-1-[(3-isopropylisoxazol-5-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.20 g, 0.75 mmol, obtained from Example 15(b)), sodium nitrite (0.060 g, 0.83 mmol) and sodium dithionite (0.26 g, 1.5 mmol) giving the title compound (0.070 g, 33% yield). MS (ESI) m/z 282 (M+1).