6-Butoxy-2-hydroxymethylpyridine → 6-Butoxypyridine-2-carbaldehyde

HRID 912700ノート

反応式

HRID 912700 の反応式
[CH2:1]([O:5][C:6]1[N:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:5][C:6]1[N:11]=[C:10]([CH:12]=[O:13])[CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 197561166-Butoxy-2-hydroxymethylpyridine

生成物 1

HCID 108450736-Butoxypyridine-2-carbaldehyde収率 84%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒2 回

実験手順

Activated manganese dioxide (2.40 g, 27.6 mmol) was added to a solution of (6-butoxy-pyridin-2-yl)methanol (0.52 g, 2.85 mmol, obtained from Example 17(c)) in anhydrous dichloromethane (5 mL). The resulting solution was heated to reflux for 2 h and then cooled to r.t. and 50 mL of dichloromethane added. The black solid was removed by filtration through silica gel and washed with dichloromethane. The combined filtrate was concentrated in vacuo providing the title compound (0.43 mg, 84%) as a light yellow oil.

後処理

  1. temperatureThe resulting solution was heated
  2. temperatureto reflux for 2 h
  3. customThe black solid was removed by filtration through silica gel
  4. washwashed with dichloromethane
  5. concentrationThe combined filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-9c4665e5dd6149efb98ef77713b1b34c
出典データセット
uspto-grants-2011_09
特許番号
US08026244B2

反応ノート

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