Hydrochloric Acid → 4-Methoxy-4-phenylpiperidine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([O:20][CH3:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][O:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
A mixture of the ester from step (b) above (8.6 g) and saturated solution of hydrogen chloride in EtOAc (100 mL) was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was washed with EtOAc, and dried in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 192 (M+1).
後処理
- customThe solvent was removed in vacuo
- washthe residue was washed with EtOAc
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-f0bc0c1662d043a1acdc163e21a2d340
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08026241B2
反応ノート
読み込み中…