Phosphorus oxychloride → 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-

反応式

[Cl:1][C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:5]2[NH:6][C:7](=O)[NH:8][C:4]=2[CH:3]=1.O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:7]1[NH:8][C:4]2[CH:3]=[C:2]([Cl:1])[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:5]=2[N:6]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 673998535-Chloro-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one

生成物 1

HCID 1785060581H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-

実験手順

The benzoimidazol-2-one from step (b) above (1.43 g, 6.0 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 254.9 (M+1).

出典と根拠

ORDレコード: ord-04d448037a564c19a56f40d72a874d35
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08026241B2

反応ノート

読み込み中…