Methylamine → [(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

HRID 912927ノート

反応式

HRID 912927 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2C(=O)C3C(=CC=CC=3)[C:11]2=O)[CH:5]=[N:6][C:7]=1[Cl:8].CN>CCO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH:10][CH3:11])[CH:5]=[N:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 6329MethylamineHCID 859654402-(5,6-Dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione

生成物 1

HCID 85663685[(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-(5,6-dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione from step (b) above (307 mg, 1.0 mmol) and methylamine (1.0 mL, 2.0 mmoL, 2.0 M in THF, Aldrich) in EtOH (10 mL) was stirred at room temperature for 4 days. The solvent was removed in vacuo to give the title compound, which was used in the next step without additional purification.

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-d706b0e8975243c98aa23758d70eda8a
出典データセット
uspto-grants-2011_09
特許番号
US08026241B2

反応ノート

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