2-Methylpiperazine, (R)- → 2-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol

HRID 912935ノート

反応式

HRID 912935 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[N:6][C:7]=1Cl.[CH3:13][C@@H:14]1[CH2:19][NH:18][CH2:17][CH2:16][NH:15]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[N:6][C:7]=1[N:18]1[CH2:17][CH2:16][NH:15][C@H:14]([CH3:13])[CH2:19]1

参加物

3

反応物 2

HCID 73304342-Methylpiperazine, (R)-HCID 772303002-(5,6-Dichloropyridin-3-yl)propan-2-ol

生成物 1

HCID 674004392-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol

実験手順

A mixture of 2-(5,6-dichloro-pyridin-3-yl)-propan-2-ol from step (b) above (140 mg, 0.68 mmol) and (R)-(−)-2-methyl-piperazine (75 mg, 0.75 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 270 (M+1).

後処理

  1. customreacted under the conditions of Example 3a

出典と根拠

ORDレコード
ord-43527ccf8a0f4dc79dc37727f1ba60ee
出典データセット
uspto-grants-2011_09
特許番号
US08026241B2

反応ノート

読み込み中…