{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461549、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.Cl[C:18]1[NH:22][C:21]2[C:23]([N+:31]([O-:33])=[O:32])=[CH:24][C:25]([C:27]([F:30])([F:29])[F:28])=[CH:26][C:20]=2[N:19]=1>CCO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:18]2[NH:22][C:21]3[C:23]([N+:31]([O-:33])=[O:32])=[CH:24][C:25]([C:27]([F:29])([F:28])[F:30])=[CH:26][C:20]=3[N:19]=2)[C@H:10]([CH3:14])[CH2:9]1参加物
4
実験手順
A mixture of {5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl}-methanol (1.21 g, 5.0 mmol, Example 150a) and 2-chloro-7-nitro-5-trifluoromethyl-1H-benzoimidazole (1.33 g, 5.0 mmol, Example 57c) in EtOH (4 mL) reacted under the conditions of Example 3c to give the title compound as a yellow solid. MS (ESI, pos. ion) m/e: 471 (M+1).