2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178519827、化合物
反応式
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][C:8]=2[C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:20]1[NH:24][C:23]2[CH:25]=[C:26]([C:38]([F:41])([F:40])[F:39])[CH:27]=[C:28]([C:29]3[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=3)[C:22]=2[N:21]=1>CCO>[F:17][C:15]([F:18])([F:16])[C:8]1[CH:9]=[C:10]([CH2:13][OH:14])[CH:11]=[N:12][C:7]=1[N:1]1[CH2:6][CH2:5][N:4]([C:20]2[NH:21][C:22]3[C:28]([C:29]4[CH:30]=[C:31]([F:37])[C:32]([F:36])=[C:33]([F:35])[CH:34]=4)=[CH:27][C:26]([C:38]([F:41])([F:39])[F:40])=[CH:25][C:23]=3[N:24]=2)[CH2:3][CH2:2]1参加物
4
実験手順
A mixture of (6-piperazin-1-yl-5-trifluoromethyl-pyridin-3-yl)-methanol from step (e) above (131 mg, 0.5 mmol) and 2-chloro-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (175 mg, 0.5 mmol, Example 51b) in EtOH (2 mL) reacted under the conditions of Example 3c to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 576 (M+1).