3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid → 5-(benzyloxy)-2-methylpyridin-4(1H)-one

HRID 913003

反応式

HRID 913003 の反応式
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][C:10]=1C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 672824263-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid

生成物 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-one収率 77.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

A suspension of 3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid (3.2 g, 0.02 mol) in DMF (30 ml) was heated in an oil bath at 120° C. for 8 hrs. The mixture was cooled to room temperature and the insoluble solid was filtered. The solid was washed with hexane and dried under vacuum for 16 hrs to give 5-benzyloxy-2-methyl-1H-pyridin-4-one (3.32 g, 77% yield).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe insoluble solid was filtered
  3. washThe solid was washed with hexane
  4. customdried under vacuum for 16 hrs

出典と根拠

ORDレコード
ord-3fdb4b6614ac4bc1b9aaaebcbce71486
出典データセット
uspto-grants-2011_09
特許番号
US08026261B2

関連ノート

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