Acetyl chloride → Dimethyl acetylphosphonate

HRID 913206ノート

反応式

HRID 913206 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][P:7]([O:10]C)[O:8][CH3:9]>>[C:1]([P:7](=[O:10])([O:8][CH3:9])[O:6][CH3:5])(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 6367Acetyl chlorideHCID 8472Trimethyl phosphite

生成物 1

HCID 2785315Dimethyl acetylphosphonate

反応条件

温度
80 °C

実験手順

Acetyl chloride (7.85 ml, 110 mmol) was cooled to 0° C. and stirred. Trimethylphosphite (11.8 ml, 100 mmol) was added drop-wise over one hour while the cooling was maintained. The mixture was then heated to 80° C. for 5 minute to remove un-reacted acetyl chloride (the flow of argon accelerates the process). The crude product was used in the next step without additional purification (theoretical yield is 15.2 g).

後処理

  1. temperaturewas maintained
  2. customto remove
  3. customun-reacted acetyl chloride (the flow of argon
  4. customThe crude product was used in the next step without additional purification (theoretical yield is 15.2 g)

出典と根拠

ORDレコード
ord-8a98fc38509e461d81c3130a305f5db4
出典データセット
uspto-grants-2011_09
特許番号
US08026278B2

反応ノート

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