Isopropanol → Stavudine DMPU

関与物質

反応条件

反応手順

Crude Stavudine (25 g, 96.7% pure, 0.1116 mole), N,N-dimethyl propylene urea (37.5 g, 1.5 parts) are added to isopropanol (50 ml, 2 volumes) and heated to 70-75° C. for dissolution. The obtained solution is stirred for 15 min. at 75° C. and cooled to 6-8° C. The precipitated product is filtered, washed with IPA and dried to give 34.1 g of Stavudine DMPU solvate (86.7%) with a chromatographic purity of 99.91%

情報源と証拠