関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Stavudine | HCID 18283 | — |
| 反応物 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Stavudine DMPU | HCID 86625622 | 87.5% |
反応手順
Crude Stavudine (25 g, 97.7% pure, 0.1116 mole), DMPU (37.5 g, 1.5 parts) are added to acetone (50 ml) and heated to 56° C. for dissolution. The obtained solution is stirred for 15 min. at 56° C. and cooled to 6-8° C. The precipitated product is filtered, washed with acetone and dried to give 34.4 g of Stavudine DMPU solvate (87.5%) with a chromatographic purity 99.93%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08026356B2 |
|---|
| 出典データセット | uspto-grants-2011_09 |
|---|
| ORD ID | ord-2bdc41f217664607a37266af142ffb4a |
|---|
| 出典メモ | uspto-grants-2011_09 |
|---|
