関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | L-Lysine monohydrochloride | HCID 69568 | — |
| 反応物 | Carbonic acid, 1,1-dimethylethyl phenyl ester | HCID 81113 | — |
| 反応物 | HCID 178418385 | HCID 178418385 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid | HCID 2733283 | — |
反応手順
A solution of L-lysine monohydrochloride (20.0 g, 109.5 mmol) and benzotriazole (14.3 g, 120.0 mmol) in a mixture of water (66.6 mL) and THF (111.0 mL) at pH 12 was treated with t-butyl phenyl carbonate (24.3 mL, 131.4 mmol) and stirred 18 hours at 60° C. The mixture, initially 2 layers, became a clear orange solution and the product was approximately 75% (NMR).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08026372B2 |
|---|
| 出典データセット | uspto-grants-2011_09 |
|---|
| ORD ID | ord-879078d31af743c9814b9a010209293f |
|---|
| 出典メモ | uspto-grants-2011_09 |
|---|
