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Bromomethylcyclopropane → 1-(Cyclopropylmethyl)-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromomethylcyclopropane | HCID 81503 | — |
| 反応物 | 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67405155 | — |
| 生成物 | 1-(Cyclopropylmethyl)-2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67406386 | — |
反応手順
Synthesized as described in Example 4 using 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.49 (s, 2H), 6.57 (s, 1H), 4.05 (d, J=6.4 Hz, 2H), 2.76 (t, J=7.6 Hz, 2H), 1.83 (m, 2H), 1.16 (m, 1H), 1.08 (t, J=7.4 Hz, 3H), 0.60 (m, 2H), 0.35 (m, 2H); MS (ES) m/z 307 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08026262B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-fcb312d43c8b4323a419bad8ef320e6d |
| 出典メモ | uspto-grants-2011_09 |