関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | N-(3-chloro-2-methylphenyl)acetamide | HCID 81969 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | N-(4-Bromo-3-chloro-2-methylphenyl)acetamide | HCID 86376 | 99.5% |
反応手順
A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCl) m/z 264 (M+2 isotope).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08026262B2 |
|---|
| 出典データセット | uspto-grants-2011_09 |
|---|
| ORD ID | ord-65dac5ab16ee462f9774f2d7d1a6a4b8 |
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| 出典メモ | uspto-grants-2011_09 |
|---|
