3,5-Bis-trifluoromethylphenylboronic acid → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-2-thienyl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

反応式

Br[C:2]1[S:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[C:12]([C:19]([F:22])([F:21])[F:20])[C:13]([C:17]#[N:18])=[CH:14][CH:15]=3)[CH:10]=[C:9]2[CH3:23])=[CH:4][CH:3]=1.[F:24][C:25]([F:40])([F:39])[C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1>>[F:24][C:25]([F:39])([F:40])[C:26]1[CH:27]=[C:28]([C:2]2[S:6][C:5]([CH2:7][N:8]3[C:16]4[C:11](=[C:12]([C:19]([F:22])([F:21])[F:20])[C:13]([C:17]#[N:18])=[CH:14][CH:15]=4)[CH:10]=[C:9]3[CH3:23])=[CH:4][CH:3]=2)[CH:29]=[C:30]([C:32]([F:33])([F:34])[F:35])[CH:31]=1

参加物

反応物 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acid

HCID 67404974HCID 67404974、化合物

生成物 1

HCID 866207001-({5-[3,5-bis(Trifluoromethyl)phenyl]-2-thienyl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

実験手順

Synthesized as described in Example 310D using 1-[(5-bromo-2-thienyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 314B) and [3,5-bis(trifluoromethyl)phenyl]boronic acid: MS (ES) m/z 531 (M−1).

後処理

customSynthesized

出典と根拠

ORDレコード: ord-2efe170c362c42bfb75d73a62ffa44a9
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08026262B2

反応ノート

読み込み中…