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HRID 913710作成日：2026年10月27日

3-(Trifluoromethyl)phenylboronic acid → 2-Methyl-4-(trifluoromethyl)-1-{[3'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913710

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
反応物1-[(3-Bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405035—
生成物2-Methyl-4-(trifluoromethyl)-1-{[3'-(trifluoromethyl)-3-biphenylyl]methyl}-1H-indole-5-carbonitrileHCID 86620702—

反応手順

Synthesized as described in Example 310D using 1-[(3-bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 318A) and [3-(trifluoromethyl)phenyl]boronic acid: 1H NMR (400 MHz, CDCl3) δ 7.73 (s, 1H), 7.65-7.35 (m, 8H), 6.81 (d, J=7.6 Hz, 1H), 6.68 (s, 1H), 5.44 (s, 2H), 2.48 (s, 3H): MS (ES) m/z 459 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08026262B2
出典データセットuspto-grants-2011_09
ORD IDord-f35702eb128646d3b5433ca4dde643aa
出典メモuspto-grants-2011_09