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Hydrochloric Acid → 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (+-)-3-Quinuclidinol | HCID 15381 | — |
| 反応物 | 1-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine | HCID 14199152 | — |
| 生成物 | 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane | HCID 19694166 | 48.6% |
反応手順
Following the procedure of Example 1, 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.78 g, 3.2 mmol) was treated with 3-quinuclidinol (0.44 g, 3.5 mmol) to give 0.52 g (39%) of the title compound as the hydrochloride, 2.5 hydrate: mp 162°-183° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723468 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ee77b780e0524603be88a42bd2c29021 |
| 出典メモ | uspto-grants-1998_03 |