Acetic Acid → N-[3-(2-{[(Ethylamino)carbonyl]amino}-1,3-benzothiazol-6-yl)-3-oxopropyl]-4-(dimethylamino)benzamide

HRID 9142

反応式

HRID 9142 の反応式
[NH2:1][CH2:2][CH2:3][C:4]([C:6]1[CH:20]=[CH:19][C:9]2[N:10]=[C:11]([NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15])[S:12][C:8]=2[CH:7]=1)=[O:5].C(N(CC)CC)C.[CH3:28][N:29]([CH3:39])[C:30]1[CH:38]=[CH:37][C:33]([C:34](Cl)=[O:35])=[CH:32][CH:31]=1.C(O)(=O)C>CN(C=O)C>[CH2:17]([NH:16][C:14]([NH:13][C:11]1[S:12][C:8]2[CH:7]=[C:6]([C:4](=[O:5])[CH2:3][CH2:2][NH:1][C:34](=[O:35])[C:33]3[CH:32]=[CH:31][C:30]([N:29]([CH3:28])[CH3:39])=[CH:38][CH:37]=3)[CH:20]=[CH:19][C:9]=2[N:10]=1)=[O:15])[CH3:18]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 8471TriethylamineHCID 44007824-(Dimethylamino)benzoyl chlorideHCID 219855561-(6-(3-Aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

生成物 1

HCID 21985527N-[3-(2-{[(Ethylamino)carbonyl]amino}-1,3-benzothiazol-6-yl)-3-oxopropyl]-4-(dimethylamino)benzamide収率 25%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Similar to the synthesis of Example 248, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 4-dimethylaminobenzoyl chloride in DMF was reacted to give the desired compound 0.025 g (25%) as an acetic acid salt. LC/MS 440.1 (M+1); LC retention time 2.86 min.

後処理

  1. customSimilar to the synthesis of Example 248
  2. customwas reacted

出典と根拠

ORDレコード
ord-6922b5b487d84e03beb86b2f7f9581c3
出典データセット
uspto-grants-2006_08
特許番号
US07091227B2

関連ノート

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