2,2-Difluoro-1,3-dioxaindan-4-amine → HCID 57955619、化合物

HRID 914213

反応式

HRID 914213 の反応式
Cl[C:2]1[N:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[C:9]([F:15])([F:14])[CH2:8][N:7]([CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[C:6]=2[N:21]=1.[F:22][C:23]1([F:33])[O:27][C:26]2[CH:28]=[CH:29][CH:30]=[C:31]([NH2:32])[C:25]=2[O:24]1>>[CH:16]1([N:7]2[CH2:8][C:9]([F:15])([F:14])[C:10](=[O:13])[N:11]([CH3:12])[C:5]3[CH:4]=[N:3][C:2]([NH:32][C:31]4[C:25]5[O:24][C:23]([F:33])([F:22])[O:27][C:26]=5[CH:28]=[CH:29][CH:30]=4)=[N:21][C:6]2=3)[CH2:20][CH2:19][CH2:18][CH2:17]1

参加物

3

反応物 2

HCID 27368912,2-Difluoro-1,3-dioxaindan-4-amineHCID 579555742-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[4,5-B][1,4]diazepin-6(7H)-one

生成物 1

HCID 57955619HCID 57955619、化合物

実験手順

The title compound was synthesized from 2-chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one and 2,2-difluorobenzo[d][1,3]dioxol-4-amine using the procedure described in the general Buchwald Reaction Scheme. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.20-1.84 (m, 9H) 3.97 (t, J=14.40 Hz, 2H) 4.50-4.70 (m, 1H) 7.14 (d, J=2.27 Hz, 1H) 7.31 (dd, J=7.45, 2.15 Hz, 1H) 8.21 (s, 1H) 9.39 (s, 1H). [M+H] calculated for C20H19F4N5O3, 454. found 454.

後処理

  1. customdescribed in the general Buchwald Reaction Scheme

出典と根拠

ORDレコード
ord-71483f93ef4d4c61ab20b813cbb38c90
出典データセット
uspto-grants-2011_09
特許番号
US08026234B2

関連ノート

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