Sodium Methoxide → 2-Fluoro-5-methoxy-4-nitrobenzoic acid
反応式
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8](F)[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][C:5]=1[F:14].[CH3:16][O-:17].[Na+]>CO>[F:14][C:5]1[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]([O:17][CH3:16])=[CH:9][C:4]=1[C:3]([OH:2])=[O:15]参加物
4
実験手順
To a solution of methyl-2,5-difluoro-4-nitrobenzoate (1 g, 4.6 mmol) in methanol (10 mL) was added sodium methoxide (95%, 393 mg, 6.9 mmol). The reaction mixture was stirred at room temperature overnight. It was then concentrated, acidified with HCl. Solid was filtered and dried to give the product as light yellow powder (728 mg, 70%). 1H NMR (400 MHz, DMSO-d6) δ ppm 3.95 (s, 3H) 7.66 (d, J=4 Hz, 1H) 8.01 (d, J=8 Hz, 1H).
後処理
- concentrationIt was then concentrated
- filtrationSolid was filtered
- customdried
出典と根拠
- ORDレコード
- ord-ee8705c0e308412f8ab6906b15f73e06
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08026234B2
反応ノート
読み込み中…