Hydrochloric Acid → HCID 86600354、化合物

HRID 914276ノート

反応式

HRID 914276 の反応式
[OH:1][NH:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][NH:13][C:14]([C:16]2[O:17][C:18]3[CH:27]=[CH:26][CH:25]=[CH:24][C:19]=3[C:20]=2[N:21]([CH3:23])[CH3:22])=[O:15])=[CH:6][CH:5]=1.[ClH:29].O>CC(O)C>[ClH:29].[OH:1][NH:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][NH:13][C:14]([C:16]2[O:17][C:18]3[CH:27]=[CH:26][CH:25]=[CH:24][C:19]=3[C:20]=2[N:21]([CH3:23])[CH3:22])=[O:15])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86600351HCID 86600351、化合物

生成物 1

HCID 86600354HCID 86600354、化合物収率 91.9%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

N-hydroxy-4-[2-(3-dimethylaminobenzofuran-2-ylcarbonylamino)ethoxy]-benzamide (22.7 g, 0.057 mol) was suspended in 2-propanol (220 ml). 12 M HCl (5.2 ml, 0.063 mol) was added in one portion and the resulting mixture was heated to reflux. Water (44 ml) was added dropwise until a homogenous solution was obtained. The reaction mixture was allowed to cool and crystallize overnight. After cooling below 5° C. for one h, the crystals were filtered and washed with 2-propanol before being dried in vacuo to to give the title compound (22.0 g) as a white solid.

後処理

  1. temperaturethe resulting mixture was heated to reflux
  2. customwas obtained
  3. temperatureto cool
  4. customcrystallize overnight
  5. temperatureAfter cooling below 5° C. for one h
  6. filtrationthe crystals were filtered
  7. washwashed with 2-propanol
  8. custombefore being dried in vacuo

出典と根拠

ORDレコード
ord-961926a92d804c308457e3be5cf3f5ba
出典データセット
uspto-grants-2011_09
特許番号
US08026371B2

反応ノート

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